Groundwater pumping has caused marked aquifer storage declines over the past century. In addition to threatening the viability of groundwater-dependent economic activities, storage losses reshape the hydrologic landscape, shifting groundwater surface water exchanges and surface water availability. A more comprehensive understanding of modern groundwater-depleted systems is needed as we strive for improved simulations and more efficient water resources management. Here, we begin to address this gap by evaluating the impact of 100 years of groundwater declines across the continental United States on simulated watershed behavior. Subsurface storage losses reverberate throughout hydrologic systems, decreasing streamflow and evapotranspiration. Evapotranspiration declines are focused in water-limited periods and shallow groundwater regions. Streamflow losses are widespread and intensify along drainage networks, often occurring far from the point of groundwater abstraction. Our integrated approach illustrates the sensitivity of land surface simulations to groundwater storage levels and a path toward evaluating these connections in large-scale models.