Nature Portfolio (Springer Nature) | March 5th, 2026
Summary
Locations with significant increased risk of all cancers, leukemias, lymphomas, and other solid tumors were collocated with PFOS/PFOA contaminated water supplies. Referen
Locations with significant increased risk of all cancers, leukemias, lymphomas, and other solid tumors were collocated with PFOS/PFOA contaminated water supplies. Referent ORs for location were attenuated after adjusting for PFOS detection and in stratified analyses for children of US-born mothers but not for Mexico-born mothers. PFOS detection was associated with higher odds of neuroblastoma (OR = 1.51, 95% CI: 1.07, 2.13) and retinoblastoma (OR = 1.83, 95% CI: 1.19, 2.79), whereas all cancers (OR = 1.07; 95% CI: 0.97, 1.18), brain tumors (OR = 1.15, 95% CI: 0.96, 1.37), and other solid tumors (OR = 1.12, 95% CI: 0.98, 1.29) had non-significant associations. PFOA detection was associated with elevated risk of retinoblastoma (OR = 1.85, 95% CI: 1.14, 3.01).