Estimating perchlorate exposure from food and tap water based on U.S. biomonitoring and occurrence data

Journal of Exposure Science & Environmental Epidemiology (Springer) | June 23rd, 2010

Human biomonitoring data show that exposure to perchlorate is widespread in the United States. The predominant source of intake is food, whereas drinking water is

Human biomonitoring data show that exposure to perchlorate is widespread in the United States. The predominant source of intake is food, whereas drinking water is a less frequent and far smaller contributor. We used spot urine samples for over 2700 subjects and estimated 24 h intake using new creatinine adjustment equations. Merging data from surveys of national health (NHANES) with drinking water monitoring (UCMR), we categorized survey participants according to their potential exposure through drinking water or food. By subtracting daily food doses of perchlorate from the oral reference dose (RfD), we derive an allowances for perchlorate in tap water for several populations. The calculated mean food perchlorate dose in the United States was 0.081 μg/kg/day compared to 0.101 μg/kg/day for those who also had a potential drinking water component. The calculated 95th percentile doses, typically falling between 0.2 and 0.4 μg/kg/day, were well below the RfD (0.7 μg/kg/day) in all populations analyzed. Children aged 6–11 years had the highest mean perchlorate doses in food (0.147 μg/kg/day), with an additional water contribution of only 0.003 μg/kg/day representing just 2% of exposure. Pregnant women had a mean food dose of 0.093 vs 0.071 μg/kg/day for all women of reproductive age. At the 95th percentile intake for both the total population and women of child-bearing age (15–44), the perchlorate contribution from food was 86% and from drinking water 14% (respectively, 30% and 5% of the RfD). At the mean for the same groups, the food to water contribution ratio is approximately 80:20. We calculate that an average 66 kg pregnant woman consuming a 90th percentile food dose (0.198 μg/kg/day) could also drink the 90th percentile of community water for pregnant women (0.033 l/kg/day) containing 15 μg/l perchlorate without exceeding the 0.7 μg/kg/day reference dose.

Estimation of groundwater residence time with deeply-derived carbon mixture considered in California

Science of the Total Environment (Elsevier) | December 16th, 2022

Groundwater has experienced long-term overdraft due to drought and human activities in California, resulting in issues of land subsidence and groundwater anthropogenic co

Groundwater has experienced long-term overdraft due to drought and human activities in California, resulting in issues of land subsidence and groundwater anthropogenic contamination. As a useful indicator of groundwater renewal rate and its residence time, groundwater age has been conventionally investigated based on 14C content and 3H concentration. However, the influence of deeply-derived (endogenic) CO2 mixture is not fully and quantitatively considered, although endogenic carbon contributes a large part of the dissolved inorganic carbon in groundwater. Combined with 3H concentration, both conventional and modified 14C-dating methods with endogenic CO2 mixture considered are employed for groundwater age determination in California. On average, the conventional groundwater 14C apparent age is overestimated by ~4.9 kyr or ~26.2 %, causing groundwater recharge rate underestimation and aquifer recovery time overestimation by ~46.0 % and ~26.2 %, respectively. High 3H concentration indicates modern water mixture in more than one fifth of groundwater samples, including those with high modified 14C apparent age (> 12 kyr, i.e., fossil groundwater) in the Central Valley and southern California, which are generally considered not to be recharged by modern water. Modern water mixture in old groundwater can potentially bring anthropogenic contamination to these groundwater resources, which should be paid attentions by the government and the managers. The results have important implications in evaluation of groundwater replenishment and its susceptibility to modern contamination in California, and in groundwater resources estimation globally.

Estrogen Receptor In Vitro Assay Linkage Studies

San Francisco Estuary Institute (SFEI) | July 30th, 2018

Our Phase 1 study indicated that it would be possible to link in vitro ER assays to in vivo endpoints (Mehinto et al. 2018). These conclusions were based on several expe

Our Phase 1 study indicated that it would be possible to link in vitro ER assays to in vivo endpoints (Mehinto et al. 2018). These conclusions were based on several experiments that were performed at the University of Florida and SCCWRP. Our conclusion was that in order to see higher order effects in Menidia, the dose of estrogens in the in vivo assay needed to be above the EC50 point for the in vitro assays. However, the dose response curve for the in vivo endpoints was broad starting at 20 ng E2/L and progressing to 20, 200 and 500 ng/L. Our Phase 1 experiments did not include the resolution to reduce uncertainty in estimated quantitative in vitro to in vivo linkage factors. While the data allowed us to extrapolate those values, it was decided that the experiment should be repeated another time with more intervening estradiol concentrations, to get a better determination. A second goal of the study was to measure estrogen equivalencies at 6 locations in San Francisco Bay, testing both the water and sediments, to determine the usefulness of the approach. Results from this study will begin to enable managers to determine whether or not additional cleanup is necessary for treated effluents that are disposed into sensitive estuarine environments.

Estuary News, April 1993

Publisher not available | April 15th, 1993

Estuary News, April 1994

San Francisco Estuary Partnership (SFEP) | April 15th, 1994

Estuary News, April 2004

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