California has experienced devastating autumn wildfires in recent years. These autumn wildfires have coincided with extreme fire weather conditions during periods of strong offshore winds coincident with unusually dry vegetation enabled by anomalously warm conditions and late onset of autumn precipitation. In this study, we quantify observed changes in the occurrence and magnitude of meteorological factors that enable extreme autumn wildfires in California, and use climate model simulations to ascertain whether these changes are attributable to human-caused climate change. We show that state-wide increases in autumn temperature (~1 °C) and decreases in autumn precipitation (~30%) over the past four decades have contributed to increases in aggregate fire weather indices (+20%). As a result, the observed frequency of autumn days with extreme (95th percentile) fire weather—which we show are preferentially associated with extreme autumn wildfires—has more than doubled in California since the early 1980s. We further find an increase in the climate model-estimated probability of these extreme autumn conditions since ~1950, including a long-term trend toward increased same-season co-occurrence of extreme fire weather conditions in northern and southern California. Our climate model analyses suggest that continued climate change will further amplify the number of days with extreme fire weather by the end of this century, though a pathway consistent with the UN Paris commitments would substantially curb that increase. Given the acute societal impacts of extreme autumn wildfires in recent years, our findings have critical relevance for ongoing efforts to manage wildfire risks in California and other regions.