Spatial analysis of residential location at birth, PFAS in public water, and childhood cancers in Southern California (2000–2019)

Locations with significant increased risk of all cancers, leukemias, lymphomas, and other solid tumors were collocated with PFOS/PFOA contaminated water supplies. Referent ORs for location were attenuated after adjusting for PFOS detection and in stratified analyses for children of US-born mothers but not for Mexico-born mothers. PFOS detection was associated with higher odds of neuroblastoma (OR = 1.51, 95% CI: 1.07, 2.13) and retinoblastoma (OR = 1.83, 95% CI: 1.19, 2.79), whereas all cancers (OR = 1.07; 95% CI: 0.97, 1.18), brain tumors (OR = 1.15, 95% CI: 0.96, 1.37), and other solid tumors (OR = 1.12, 95% CI: 0.98, 1.29) had non-significant associations. PFOA detection was associated with elevated risk of retinoblastoma (OR = 1.85, 95% CI: 1.14, 3.01).